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I. Perini

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Open access Sep 2026

482. Altered GABAb receptor–mediated cortical inhibition in heavy alcohol use: evidence from a pharmaco-TMS study using baclofen

Dose- and group-dependent modulation of GABAbR-mediated cortical inhibition by baclofen is demonstrated, and LICI emerges as a sensitive, non-invasive biomarker of GABAbR function and pharmacodynamic target engagement, with potential utility for stratifying neurobiological heterogeneity and informing the development of...

C. Montemitro, I. Perini, M. Heilig · 0 citations

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