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Author

I. Shimomura

2 papers indexed here

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Open access Sep 2026

Plasma Lipids Associated with Endothelial Dysfunction in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Lipidomic Analysis

Patients with diabetes often develop abnormalities in lipid metabolism that can promote diabetic complications. Lipidomic studies have demonstrated that certain plasma lipid species are associated with the development of cardiovascular diseases. However, the plasma lipids associated with endothelial dysfunction remain...

Naohiro Taya, N. Katakami, Kazuo Omori et al. · 0 citations
Open access Oct 2026

ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity

Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, that function as modulators of both local and systemic metabolism. Using mice in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα+ mesenchymal progenitors (Pα-ALIXKO mice), we demonstrate a critica...

Y. Uehara, Hirofumi Nagao, Aoki Tobimatsu et al. · 0 citations

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