Author

I. Shlaifer

3 papers indexed here

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Open access Sep 2026

The Parkinson 's Disease Associated BAP1/ASXL3 Complex Regulates the Internalization of Î±-Synuclein Fibrils by Reprogramming the Cell Surface Glycoproteome

A central hallmark of Parkinson's disease (PD) is the spread of -Synuclein (-Syn) aggregates, which is thought to contribute to its progressive nature. To better understand the mechanism of cellular internalization of -Syn fibrils, we conducted a genome wide CRISPR activation (CRISPRa) screen to identify genetic modifi...

N. Karpilovsky, T. Goiran, K. Senkevich et al. · medRxiv · 0 citations

Open access Sep 2026

Phosphorylated α-Synuclein shapes changes in brain structure, task-related activity and functional connectivity in M83 mice

The deleterious effects of pS129 accumulation are demonstrated and a toxic role played by these aggregates are argued in favor of a toxic role played by these aggregates.

Amr Eed, Vladislav Novikov, Shahrzad Bahrampour et al. · bioRxiv · 0 citations

Open access Sep 2026

USP15 REGULATES NEUROINFLAMMATION AND DRIVES PATHOGENESIS IN SYNUCLEINOPATHIES

It is shown that ablation of Usp15 in astrocytes and in microglia protects against lethal neuroinflammation in vivo, and a strong cis-acting eQTL directing high USP15 expression in CD14+ myeloid cells is detected in humans.

Nassima Fodil, E. del Cid-Pellitero, V. Piscopo et al. · bioRxiv · 0 citations