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Aug 2026

Prevalence of High Tumor Mutational Burden Among Pediatric Patients With Solid Tumors.

High tumor mutational burden (TMB-H), defined as ≥10 non-driver somatic mutations per mega base of genome sequenced (mut/Mb), and high microsatellite instability (MSI-H), which can lead to TMB-H, are both associated with response to the immunotherapy pembrolizumab. Data from the KEYNOTE-158 study demonstrated that the...

Wen-Jun Zhong, E. Dettman, Lei Zhang et al. · 0 citations
Review Open access Sep 2026

Characteristics and Treatment Patterns of Early Stage Melanoma: Results from a Multisite Chart Review.

BACKGROUND Early stage melanomas are clinically heterogeneous and real-world treatment patterns in early stage cutaneous melanoma are poorly characterized. OBJECTIVE The purpose of this study was to characterize real-world treatment patterns among patients with early stage cutaneous melanoma. METHODS A retrospectiv...

C. Costello, Maria L. Wei, James M. Isaacs et al. · 0 citations

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