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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

I. Taladriz-Sender

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Case report Aug 2026

The variant c.2766+3A>T in DPYD leads to exon 21 skipping and is associated with DPD deficiency and severe fluoropyrimidine toxicity.

A 50-year-old male with colorectal cancer who received adjuvant XELOX and developed life-threatening grade 3-4 toxicities is described, and a c.2766+3A>T variant leads to a non-functional DPD enzyme and is a likely cause of severe fluoropyrimidine-related toxicity.

S. Salvador-Martín, I. Taladriz-Sender, Paula Zapata-Cobo et al. · 0 citations

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