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This case highlights the complexity of managing immunocompromised patients with unexplained fever and neurological symptoms, emphasizing the need for further research into the potential neurological effects of Giardia infection.
Patients with TNFRSF13B variants display broad phenotypic heterogeneity ranging from asymptomatic carriage to CVID and combined immunodeficiency phenotypes, suggesting that coexisting genetic variants and exposomal factors likely determine the clinical expression and disease severity.
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