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I-Ting Teng

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Open access Sep 2026

Co-administration of intranasal parainfluenza virus vaccines expressing antigenically distinct SARS-CoV-2 S antigens elicits broad and durable immunity in hamsters

ABSTRACT Intranasal COVID-19 vaccines with the ability to induce broad and durable mucosal and systemic immunity would be useful as stand-alone vaccines or in combination with injectable vaccines. We evaluated in hamsters the breadth of immunity and durability of protection elicited by co-administration of two live-att...

Hong-Su Park, Yumiko Matsuoka, Celia Santos et al. · 0 citations
Open access Aug 2026

Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants

Hundreds of recall and de novo neutralizing monoclonal antibodies are isolated and characterized after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans to reveal the distinct contributions of recall and de novo antibodies to a balanced immune response and underscore the benefit of updated boost...

T. Johnston, Shuk-Hang Li, M. Painter et al. · 2 citations
Open access Aug 2026

Vaccine imprinting drives increased SARS-CoV-2 variant infection in children

The dependence of effective variant-specific antibodies on vaccination history is shown which may explain birth-year influence on differential susceptibility to SARS-CoV-2 variants XFG and BA.3.3.2, and it is suggested that vaccination regimens in children should prioritize neutralization breadth.

T. Johnston, Rahul Subramanian, Wakinyan Benhamou et al. · 0 citations

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