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Author

I. Tzoulaki

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Open access Sep 2026

A novel framework leveraging non-causal associations reveals shared pathways linking inflammation and cancer risk

Confounding is a central challenge in observational studies. Here, we propose a framework for identifying confounders of two non-causally related traits by employing cross-trait pleiotropy analysis to detect genetic loci that affect both traits and multi-trait colocalisation to identify molecular phenotypes mediating t...

J. Yarmolinsky, F. Cavallo, F. Koskeridis et al. · 0 citations
Open access Jul 2026

Identifying protein biomarkers and therapeutic targets in psoriasis through integrative genomic, proteomic and transcriptomic analysis

Plasma proteins are promising biomarkers and potential drug targets in psoriasis. We conducted a two-sample Mendelian randomisation analysis integrating protein quantitative trait loci from UK Biobank and deCODE genetics with a psoriasis GWAS meta-analysis of 36,466 cases. To strengthen causal inference, we performed c...

D. Meena, C. V. Chalitsios, J. Huang et al. · 0 citations

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