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I. V. Kulakov

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Review Open access Sep 2026

The Epoxybenzooxocine Core of Integrastatins and Analogs: A Comprehensive Review of Structure, Synthetic Approaches, and Biological Applications

Integrastatins and their biogenetic counterparts possess a rare heterotetracyclic framework containing an unprecedented [6/6/6/6]-tetracyclic skeleton and a central [3/3/1]-bicyclic ketal core with high pharmaceutical potential, particularly due to their potent anti-HIV-1 integrase activity. Despite their promising sca...

Aida S. Rakhimzhanova, I. Pustolaikina, A. Kurmanova et al. · 0 citations

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