Open access
Aug 2026
DNA methylation signatures of sporadic colorectal cancer with microsatellite instability
ABSTRACT Colorectal cancer (CRC) is a heterogeneous disease shaped by genetic and epigenetic alterations. Approximately 20% of CRCs exhibit widespread CpG island hypermethylation, termed the CpG Island Methylator Phenotype (CIMP), frequently accompanied by MLH1 promoter hypermethylation, deficient mismatch repair (dMMR...
Rebecca Ward, Molly Endicott, B. Mallabar-Rimmer et al.
· Epigenetics · 0 citations