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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ibrahim Topcu

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Open access 2026

Artificial neural network–based classification of gliomas using molecular and clinical data

Gliomas are the most common primary brain tumors, characterized by substantial heterogeneity in clinical course and prognosis. Accurate tumor grading remains essential for therapeutic decision-making and survival prediction. The integration of molecular and clinical variables into predictive models may improve the diag...

Tugay Atalay, Ibrahim Topcu · 0 citations
Open access Oct 2026

Impact of Neoadjuvant Chemotherapy on Pathological Outcomes and Survival in Muscle-Invasive Bladder Cancer: A Single-Center Retrospective Analysis

Neoadjuvant chemotherapy (NAC) is recommended for patients with muscle-invasive bladder cancer (MIBC); however, its impact on survival outcomes remains controversial in real-world clinical settings. This retrospective observational study evaluated the effect of NAC on pathological outcomes and overall survival among pa...

Ibrahim Topcu, Bulut Dural, Ö. Yıldırım et al. · 0 citations
Open access Sep 2026

Renoprotective Effects of Vortioxetine in Experimental Renal Ischemia–Reperfusion Injury: An Investigation of Oxidative Stress, Inflammation, and Apoptotic Signaling

Renal ischemia–reperfusion (I/R) injury is a leading cause of acute kidney injury and is driven by oxidative stress, sterile inflammation, and regulated cell death. Vortioxetine (VOR), a multimodal antidepressant, carries anti-inflammatory and antioxidant activity beyond its neuropsychiatric actions, but has not been t...

Resul Çiçek, Ibrahim Topcu, Bulut Dural et al. · 0 citations
Jul 2026

Strong Correlation but Moderate Agreement: Comparison of Clavien-Dindo and Clavien-Madadi Classification Systems in Pediatric Percutaneous Nephrolithotomy.

Despite strong correlation, CD and CM classifications are not interchangeable and the CD system may overestimate complication severity in pediatric patients due to its anesthesia-based grading criteria, whereas the CM system appears more aligned with pediatric clinical practice.

Ibrahim Topcu, Resul Çiçek, Bulut Dural et al. · 0 citations

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