Beyond the full-length toxin: The metalloprotease domain of Pictolysin-III retains key functional properties and cellular activity.
It is demonstrated that the metalloprotease domain constitutes an active functional unit of Pictolysin-III, with rMD-Pp more closely reproducing the functional properties of the native toxin than rMD-Ec, however, the two recombinant preparations differed in their biochemical and biological profiles.