Author

Ilya E. Vorontsov

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Open access Aug 2026

An expanded codebook of human transcription factor DNA-binding specificity

Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs1. Furthermore, even for well-characterized TFs, it remains controversial the degree to which motif...

A. Jolma, Kaitlin U. Laverty, Ali Fathi et al. · Nature · 3 citations

Open access Sep 2026

EPIC: An open community challenge for sequence-based prediction of transcription initiation in five non-model metazoans

Predicting gene expression from DNA sequence is a central problem with critical biological and clinical implications. Recent sequence-to-function models are reported to achieve improved performance, yet it remains unclear how much of what they learn reflects genuine principles of eukaryotic transcription initiation and...

Ilya E. Vorontsov, Nikita Gryzunov, Bayley R. McDonald et al. · bioRxiv · 0 citations

Review Open access Aug 2026

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors

There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...

A. Jolma, A. Hernandez-Corchado, A. Yang et al. · Nature Methods · 3 citations