Predictor-Guided Latent Space Codon Optimization for Maximizing Protein Expression
Codon optimization, the process of selecting synonymous codons to improve mRNA translation efficiency and protein expression, is central to therapeutic protein production and mRNA vaccines, yet it remains a hard problem. The design space is discrete and combinatorially large, precluding gradient-based methods, and exis...
Alberto Caron, Tian-Yu Cui, Dmytro S. Lituiev et al.
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