Author

Iman H. Hasan

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Sep 2026

Indole-3-acetic acid attenuates doxorubicin-induced liver injury by modulating oxidative stress, inflammation, and VEGF/FLT1 and Keap1/Nrf2/HO-1 signaling.

Doxorubicin (DOX) remains an effective antineoplastic agent; however, its clinical use is frequently limited by adverse effects, including hepatotoxicity. Indole-3-acetic acid (IAA), a naturally occurring tryptophan-derived metabolite, has recently attracted attention because of its cytoprotective and immunomodulatory...

Iman H. Hasan, Q. Alqahtani, Samiyah Alshehri et al. · Tissue & Cell · 0 citations

Open access Jul 2026

Involvement of NOD1/NF-κB/MAPK pathway in the protective effect of procyanidin B2 against methotrexate-induced nephrotoxicity

Objective Methotrexate (MTX) is a very effective agent used to treat rheumatoid arthritis and malignant diseases. Despite its usefulness, the long-term use of MTX is associated with multiorgan toxicities, including kidney injury. Thus, there is a necessity to explore a renoprotective agent with low side effects. Procya...

A. Al Tuwaijri, Ahlam M. Alhusaini, W. Sarawi et al. · Science in progress · 0 citations

Open access Aug 2026

Liposomal Nano-Curcumin Attenuates Cisplatin-Induced Hepatotoxicity in Rats with Concomitant Regulation of Wnt/β-Catenin/GSK-3β and Nrf2 Signaling

N-Cur mitigates oxidative damage and inflammation, thereby preserving hepatic function during CDDP-based chemotherapy, and demonstrates significant potential as a hepatoprotective agent when administered concomitantly with CDDP chemotherapy.

Q. Alqahtani, M. Atteya, T. Almatrafi et al. · Biomedicines · 0 citations