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In-Suk Kim

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Open access Aug 2026

INDELVAR: structure-informed prediction of in-frame indel pathogenicity with calibrated PP3/BP4 thresholds

INDELVAR, a random forest model for in-frame insertions and deletions of 1-10 amino acids that integrates 37 features describing AlphaFold-derived wild-type structural context, evolutionary conservation, local sequence change, gene constraint, and curated protein annotations, is developed.

Eun-Joo Ji, Seung-Hwan Oh, In-Suk Kim · bioRxiv · 0 citations