Advanced Intranasal Lipid-Based Nanocarrier System for Targeted Nose-to-Brain Delivery of Vortioxetine Hydrobromide: From Formulation to In vivo Pharmacokinetics
Objective: Vortioxetine HBr is a multimodal antidepressant with a very poor aqueous solubility (50 µg base/ml at pH 7.4) and an oral bioavailability of approximately 75% due to hepatic first-pass metabolism. Nose-to-brain drug delivery can bypass hepatic first-pass metabolism and achieve targeted drug therapy by circum...