Open access
Aug 2026
Binary-SPA: a reference-free method for cell annotation in high-resolution spatial transcriptomics
Abstract Accurate cell annotation is a primary challenge in spatial transcriptomics (ST). Current approaches primarily rely on label transfer from single-cell RNA sequencing (scRNA-seq) reference or marker-based clustering. While these methods are widely used, they have critical limitations. Label transfer approaches d...
Hong-Hao Bi, Wenjie Cai, Pan Wang et al.
· Nucleic Acids Research · 0 citations