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Author

Indrani Datta

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Open access Oct 2026

Generation of a CRISPR/Cas9-corrected isogenic control iPSC line (NIMHi001-A-1) from a Parkinson's disease Patient-Derived iPSC line carrying the LRRK2 I1371V mutation.

The NIMHi001-A-1 line demonstrated trilineage differentiation potential and tested negative for mycoplasma, providing an isogenic platform to investigate LRRK2 I1371V-specific pathomechanisms and evaluate therapeutic strategies.

Roon Banerjee, Khushboo Singh, Ujaswini Gogoi et al. · 0 citations
Review 2026

Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.

This review synthesises current evidence on how mutations in Leucine-Rich Repeat Kinase 2 (LRRK2), the most common genetic cause of familial PD, fundamentally corrupt glial handling of extracellular α-synuclein and evaluates emerging therapeutic strategies targeting LRRK2 kinase activity, NLRP3 inflammasome activation,...

Indrani Datta, Dibyam Debasish Sahu · 0 citations

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