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It is established that a minimal, sequence-encoded interaction hierarchy can programme long-range supramolecular order, providing a general framework for how short peptides can encode complex, symmetry-defined architectures.
Almost all membrane proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present ProSecCO (Protein Secretion in Cell-free via synthetic Operons), which is a cell-free protein synth...
Findings identify cholesterol as a pivotal regulator of serum protein interactions and biodistribution, providing valuable insights for the rational design of efficient, organ-specific liposomal drug delivery systems.
The results show how amyloid polymorphs could differentially modulate pathogenicity and the importance of environmental conditions on the molecular features of amyloid nucleation may be critical for design and stability of future protein biologics beyond therapeutic insulin.
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