Author

Ioana Streață

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Review Open access Oct 2026

Diagnostic Yield and Clinical Actionability of Genetic Testing in Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis

Genetic testing is increasingly central to the evaluation of neurodevelopmental disorders (NDDs), yet most evidence emphasises diagnostic yield rather than whether findings change clinical care. We conducted a systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISM...

Alexandra-Aurora Dumitra, Ioana Streață, Adina Turcu-Știolică et al. · International Journal of Mol... · 0 citations

Review Open access Aug 2026

From FGFR3 Hyperactivation to Disease-Modifying Therapy in Pediatric Achondroplasia: Molecular Mechanisms, Clinical Evidence, and Emerging Treatments

Achondroplasia is increasingly understood as a disorder of dysregulated growth plate signaling rather than solely a condition of reduced stature and vosoritide provides clinical proof that pharmacological modulation of FGFR3-related signaling can improve growth velocity.

R. Șerban, Andreea-Mădălina Mituț-Velișcu, Alexandra-Aurora Dumitra et al. · Children · 0 citations

Review Open access Aug 2026

Association of germline ABCB1 and ERCC1 polymorphisms with CDK4/6 inhibitor-induced neutropenia in patients with breast cancer: a systematic review and meta-analysis

Preliminary findings suggest that ABCB1 rs1045642 T-carrier status may be associated with CDK4/6 inhibitor–induced neutropenia in European/Caucasian patients, with a concordant trend for rs1128503 findings.

Marina-Daniela Dimulescu, C. Lungulescu, A. Riza et al. · Frontiers in Pharmacology · 0 citations