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Ioanna Sandvig

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Open access Sep 2026

Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization

The apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer’s disease (AD), which accounts for the vast majority of AD cases. Ion dysfunction has emerged as a central mechanism involved in APOE4-related pathology, reflecting the importance of ion homeostasis for cell me...

Marthe Bendiksvoll Grønlie, Anna Mikalsen Kollstrøm, Axel Sandvig et al. · 0 citations

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