Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a multidimensional model capable of captu...
S. Gandolfo, Ioannis Parodis, Daniele Mauro et al.· Journal of Autoimmunity· 0 citations
Antibodies against the Dense Fine Speckled 70 kDa protein (anti-DFS70), associated with the anti-cell 2 (AC-2) pattern on immunofluorescence HEp-2 cells, represent a frequent finding in antinuclear antibody (ANA) testing, particularly among healthy individuals, and have been proposed as an exclusion marker for systemic...
Federica Zucca, Valeria Longoni, D. Nikolopoulos et al.· Autoimmunity Reviews· 0 citations
BACKGROUND
Lupus arthritis (LA) is a major determinant of clinical outcomes and treat-to-target strategies in systemic lupus erythematosus (SLE), yet its molecular basis remains elusive.
METHODS
Whole-blood RNA sequencing from 170 SLE [67 with active arthritis but quiescent disease in other organs; 42 with only mucoc...
G. Sentis, C. Kalantzi, S. Flouda et al.· Journal of Autoimmunity· 0 citations
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