Author

Ioscani Jiménez del Val

2 papers indexed here

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Open access Sep 2026

Next-gen glycoengineering: combining cellular and metabolic engineering to fine-tune mAb β1,4-galactosylation

N-linked Fc galactosylation drives variability in therapeutic mAb quality, affecting complement-dependent cytotoxicity and ADCC. Current control strategies suffer from narrow ranges, productivity loss, or unwanted glycoforms. Here, we combine metabolic and cellular glycoengineering by feeding 2-deoxy-2-fluorogalactose...

Apostolos Tsopanoglou, Mina Ghahremanzamaneh, Itzcóatl Gómez Aquino et al. · bioRxiv · 0 citations

Open access Aug 2026

Unmasking Glycoforms: Lectin-Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in Chinese Hamster Ovary Cells.

Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell-surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering...

Cristina Abascal Ruiz, Sheryl Y. T. Lim, J. Brink et al. · Biotechnology and Bioenginee... · 0 citations