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Open access Oct 2026

YY1 phosphorylation links non-apoptotic caspase-8 signaling to MASH fibrosis

Background & Aims Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of chronic liver disease, and liver fibrosis is the principal determinant of disease progression and clinical outcome. We recently showed that non-apoptotic caspase-8 in hepatocytes is upregulated in MASH and leads to the induc...

Xiao-Bo Wang, Eui-Jung Jung, Lanuza A. P. Faccioli et al. · 0 citations

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