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Irfan Hussain

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Review Open access Aug 2026

A Comprehensive Review Tracing the Evolution of Volumetric Medical Imaging Analysis from Classic CNNs to Emerging AI-Agents

Volumetric medical imaging has redefined modern healthcare, enabling precise diagnosis, prognosis, and treatment planning. During the past decade, the field has undergone a paradigm shift from classical deep learning architectures to multimodal, agent-driven AI systems capable of uncovering rich volumetric biomarkers and utilizing heterogeneous data for predictive and generative modeling. Existing surveys are fragmented, focusing on specific models or tasks instead of offering a unified view of volumetric learning evolution. This study traces the evolution from classical models (Convolutional Neural Networks, Recurrent Neural Networks, and transformers) to generative approaches (Variational Autoencoders, Generative Adversarial Networks, and diffusion models) and finally to foundation models and AI-agents that enable advanced reasoning and adaptive clinical workflows. As the reported performance varies substantially across datasets, imaging modalities, and evaluation protocols, this review emphasizes methodological evolution, representative innovations, and practical implications rather than direct numerical ranking of competing architectures. For each paradigm, we critically assess methodological innovations, strengths, limitations, and comparative performance in segmentation, classification, detection, reconstruction, and report generation. Beyond synthesizing progress, we identify persistent challenges, including data scarcity, generalization between institutions, and clinical trustworthiness, and outline emerging frontiers in multimodal fusion, explainable AI, and human–AI collaboration. This review provides a unified framework for understanding the evolution of volumetric medical imaging and offers actionable insights for researchers, clinicians, and industry practitioners, contributing to the development of reliable, interpretable, and clinically deployable next-generation medical AI systems. To support further research, we provide a GitHub repository that includes popular 3D medical imaging datasets with recent 3D models in our shared GitHub repository (https://github.com/Owais-CodeHub/3D-Medical-Imaging-Review).

Muhammad Owais, Muhammad Zubair, Daniya Najiha Abdul Kareem et al. · 8 citations · ⚡1
Review Aug 2026

Uncertainty-Aware Decision Making in Multimodal Large Language Models

Multimodal large language models (MLLMs) increasingly answer questions whose correctness depends on visual, textual, temporal, acoustic, document, chart, or embodied evidence. Their failures are therefore not only linguistic. A fluent answer may conceal poor input quality, a perceptual error, weak grounding, conflict between modalities, unstable reasoning, distribution shift, or a question that is not answerable from the supplied evidence. This survey organizes the literature on uncertainty-aware MLLMs around a decision-centered framework: uncertainty sources give rise to observable signals, signals must be calibrated or controlled for risk, and calibrated uncertainty should determine the system action. We review work on token and logit uncertainty, semantic disagreement, perturbation instability, grounding and attribution scores, verbalized confidence, verifier and judge scores, conformal prediction, selective answering, abstention, clarification, retrieval, self-checking, and escalation. The central argument is that uncertainty should not be evaluated only as a confidence number; it should be evaluated by whether it improves behavior under insufficient, conflicting, shifted, or high-risk multimodal evidence. We position this survey against text-only uncertainty and abstention surveys, broad MLLM surveys, MLLM hallucination surveys, and safety-oriented reviews. We conclude with open problems in source-aware decomposition, action-aware benchmarks, calibration under shift, black-box uncertainty estimation, broader modality coverage, reproducible reporting, and human-centered uncertainty communication.

Abderrahmene Boudiaf, Irfan Hussain, Sajid Javed · 0 citations