Open access
Jul 2026
CELF2 promotes 4R Tau splicing via nuclear clustering and drives cognitive dysfunction in tauopathy models
It is shown that IDR-mediated assembly of the RNA-binding protein CELF2 coordinates tau exon 10 splicing through interactions with NOVA2 and SFPQ, regulating 4 R tau expression and neurological function and impacts tau-related neurodegeneration.
Xin Li, Ishana Syed, Rashmi Adhikari et al.
· Nature Communications · 0 citations