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Isra Sadiya

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Open access Aug 2026

Conserved structural elements in Gα subunit switch regions are necessary for efficient inactivation by RGS proteins.

Heterotrimeric G proteins (αβγ) function as molecular switches that regulate intracellular signaling downstream of G protein-coupled receptors (GPCRs). Gα subunits cycle between an inactive GDP-bound state and an active GTP-bound state that engages downstream effectors. The duration of Gα-mediated signaling is primaril...

Isra Sadiya, Anna Fassler Bakhman, Meirav Avital-Shacham et al. · 0 citations

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