Israr Hussain

Integrated expression profiling and structure-based drug discovery identify EGFR as a druggable target and Tripterygium wilfordii phytochemicals as potential therapeutics for autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive genetic disorder characterized by renal cyst formation and eventual kidney failure, with limited effective therapeutic options. In this study, we employed an integrated computational framework combining microarray-based gene expression profiling, net...