Open access
Sep 2026
Coupling fatty acid biosynthesis to β-oxidation enhances the biosynthesis of malonyl-CoA-dependent polyketides.
Malonyl-CoA is a major extender unit in polyketide biosynthesis; however, in Escherichia coli, it is predominantly consumed by fatty acid biosynthesis, limiting its availability for heterologous polyketide production. Here, we engineered a fatty acid biosynthesis-β-oxidation carbon-recycling pathway (FABOX pathway) tha...
Takatoshi Suematsu, Shumpei Asamizu, Manami Takama et al.
· Metabolic Engineering · 0 citations