Open access
Sep 2026
Albumin uptake through FcRn promotes tumor-associated macrophage maturation and albumin-bound immunotherapy response.
It is shown that tumor-associated macrophages are the dominant nonmalignant albumin-accumulating population in mouse tumors and exhibit the highest per-cell uptake and albumin conjugation prolonged STING-agonist circulation and improved antitumor efficacy versus free agonist in syngeneic tumors.
Hui-Yu Hu, F. Jiang, S. Park et al.
· Cell Reports · 0 citations