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Author

Ivan Mikicic

2 papers indexed here

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Open access Sep 2026

Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation

Early embryogenesis relies extensively on maternally deposited products until zygotic genome activation, yet the dynamics for the synthesis of new proteins in mammalian embryos remains poorly characterized. To address this, we applied pulsed stable isotope labelling by amino acids in cell culture (pSILAC) combined with...

L. Schmidt, Maico Y. Lechner, Javier Martín-González et al. · 0 citations
Open access Sep 2026

Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response

Polyubiquitin chain geometry dictates functional consequences of ubiquitylation (1, 2). Although branched polyubiquitin chains are abundant in cells, little is known about their functions (3–5). Here we show that branching on the DNA replication factor PCNA, mediated by the ubiquitin-conjugating enzyme UBE2K and involv...

Kirill Petriukov, Christian Renz, Markus S. Schraft et al. · 0 citations

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