Review
Open access
Nov 2026
Beyond Clonal Hematopoiesis: Somatic Hematopoietic Mutations as Drivers of Cardiovascular Disease and Targets for Precision Therapy
The reviewed data indicate that driver mutations in DNMT3A, TET2, ASXL1, JAK2, TP53 and PPM1D can promote chronic myeloid inflammation, NLRP3/IL-1β and IL-6 signaling, endothelial dysfunction, atherosclerotic plaque instability, myocardial fibrosis, adverse remodeling, thrombosis, arrhythmias and cardio-oncology compli...
M. Boz, Ivana Krajina, Z. Lewandowska et al.
· Cardiogenetics · 0 citations