4-Nerolidylcatechol binds to Derlin-1 and modulates endoplasmic reticulum stress markers of androgen-independent prostate cancer cells.
Castration-resistant prostate cancer (CRPC) is a lethal disease characterized by androgen receptor-independent activation mechanisms that promote prolonged or unresolved endoplasmic reticulum (ER) stress. Consequently, these cells rely on the endoplasmic reticulum-associated degradation (ERAD) pathway, specifically Der...