Targeting the Orai1 CRAC channel: translating molecular insights into therapeutic progress.
INTRODUCTION The Ca2+ release-activated Ca2+ (CRAC) channel, triggered by the interaction between the Ca2+ sensor STIM1 and Orai1, is the primary mediator of store-operated calcium entry (SOCE). Dysregulation of this process drives numerous human pathologies, particularly immune disorders and cancer hallmarks. Due to i...