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Author

J. Alegre-Díaz

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Oct 2026

Plasma omega-3 and omega-6 polyunsaturated fatty acid levels and risk for total mortality: The Mexico City Prospective Study.

In this large cohort, higher circulating omega-3 fatty acid levels, including DHA, were associated with lower all-cause mortality, and the relevance of circulating fatty acid profiles in diverse genetic and dietary contexts is highlighted.

Edgar Denova-Gutiérrez, N. Tintle, Heidi T. M. Lai et al. · 0 citations
Open access Aug 2026

PKHD1L1 affects fertility in women

Reproduction is one of the most fundamental biological processes in the human body, yet the molecules governing it remain incompletely understood. Here, we have characterized the role of PKHD1L1 and its globally relatively common splice donor variant rs17368310 in female fertility. We demonstrate estrogen-responsive ex...

E. Kapiainen, M. Karjalainen, P. Petrov et al. · 0 citations
Open access Oct 2026

Cross-sectional associations of smoking and alcohol intake with NMR-measured lipid and metabolic biomarkers in over 100,000 Mexican adults

Smoking and alcohol use increase disease risk through metabolic disruption, vascular damage, and chronic inflammation. Plasma-based nuclear magnetic resonance (NMR) metabolomics can profile lipoproteins, amino acids, and inflammatory biomarkers linked to lifestyle-related disease risk. We examined cross-se...

T. Hubbard, E. Trichia, J. Alegre-Díaz et al. · 0 citations
Review Open access Sep 2026

Mexico City Prospective Study: cohort profile update

Abstract To fully understand the causes of human disease worldwide, large blood based prospective studies are needed in a range of populations with different healthcare settings and exposures to environmental and genetic risk factors. The Mexico City Prospective Study, updated in this cohort profile, was established in...

J. Emberson, J. Alegre-Díaz, J. Berumen et al. · 1 citation
Open access Sep 2026

Within-family effect of ancestry on complex traits in a Mexican population.

Overall, this study provides an experimental design to study between-ancestry genetic effects and identifies significant ancestry differences for height, type 2 diabetes and metabolic traits in a genetically diverse population from Mexico City.

Si-Qi Wang, J. Berumen, A. Vergara-Lope et al. · 0 citations
Open access Sep 2026

Enhanced power and transferability for genetics-driven metabolomic biomarker discovery in admixed American cohorts

Among AMR participants of the All of Us cohort, using MCPS-trained (vs. INTERVAL-trained) models to predict metabolomic traits yielded five times as many significant associations across three cardiometabolic diseases: ischaemic heart disease, type 2 diabetes, and chronic kidney disease.

T. Oreskovic, D. Jin, E. Trichia et al. · 0 citations
Open access Aug 2026

Blood Pressure, Kidney Function, and Kidney Mortality Among Mexican Adults.

Elevated BP as a major modifiable risk factor for kidney failure mortality, CKD, and albuminuria is highlighted in this large prospective study in Mexican adults.

Doreen Zhu, P. Kuri-Morales, Rachel Wade et al. · 0 citations

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