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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

J. Alumkal

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2 papers indexed here

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Sep 2026

Prospective Evaluation of Circulating Tumor DNA in Metastatic Hormone-Sensitive Prostate Cancer.

PURPOSE There are few established prognostic biomarkers in metastatic hormone-sensitive prostate cancer (mHSPC). Disease volume and timing of metastases are prognostic and predictive factors but may be inadequate due to heterogeneity. Circulating tumor DNA (ctDNA) provides both circulating volume (tumor fraction [TF])...

C. Nguyen, I. Tsung, Jessica K. Lee et al. · 0 citations
Open access Aug 2026

Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.

Lineage plasticity, or transdifferentiation, is increasingly recognized as a resistance mechanism to androgen receptor (AR) inhibition in prostate cancer. Lineage plasticity is characterized by loss of AR signaling and epithelial differentiation, along with activation of stemness-associated pathways, epithelial-mesench...

W. Storck, Diana Flores, A. Kumaraswamy et al. · 0 citations

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