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J. An

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Meta-analysis Open access Aug 2026

Mortality and cardiovascular risk of triglyceride-glucose and derived indices in cardiovascular-kidney-metabolic syndrome stages 0-3: a dose-response meta-analysis

TyG-derived indices, particularly TyG-WC, TyG-WHtR, and CTI, show stronger risk associations than the TyG index for cardiovascular risk assessment in CKM populations, whereas the clinical utility of TyG-BMI is relatively limited.

J. An, Xue He, Qian-Ying Hao et al. · 0 citations
Open access Aug 2026

Cardiovascular-kidney-metabolic health, genetic susceptibility, and incident cancer risk: a prospective UK biobank cohort and machine learning study

Background It remains unclear whether cardiovascular-kidney-metabolic (CKM) syndrome and genetic susceptibility are associated with cancer incidence. This study aims to evaluate the associations between CKM health status, genetic susceptibility, and cancer incidence, and to develop a machine learning-based prediction m...

Xue He, J. An, Chun-Jia Yan et al. · 0 citations
Open access Jul 2026

Association of accelerometer-measured physical activity and the risk of incident cardiovascular diseases within the AHA cardiovascular-kidney-metabolic syndrome 0–4 framework: a prospective cohort of the UK Biobank

Associations between physical activity and incident CVD differ across CKM stages 0–3, with LPA and MVPA exhibited nonlinear L-shaped relationships across stages 0–3 and MVPA in stage 3 exhibited a U-shaped CVD risk curve.

J. An, Xue He, Jing-Yi Ding et al. · 0 citations

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