Background Archaeal extra-chromosomal elements (ECEs) play key roles in archaeal host biology and evolution, yet little is known about their diversity and interactions with each other. Here, we report 42 complete 66 - 165 kbp genomes: 23 “Klingons”, 8 “Romulans” and “Romulan-like elements”, and 11 “Ferengi”, three new...
Natasha J. Jablonsky, Ling-Dong Shi, Daniela S. Aliaga Goltsman et al.· bioRxiv· 0 citations
The strategy of integrating metagenomic bioprospecting with cell-free screening and cell-based engineering will accelerate the discovery and optimization of orthogonal translation systems for genetic code expansion.
Kosuke Seki, Michael T. A. Nguyen, Petar I. Penev et al.· ACS Synthetic Biology· 0 citations
A protein design strategy is used that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs, establishing a strategy for creating non-natural RNA-guided nucleases and conformatio...
Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk et al.· Science· 2 citations
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