Human populations differ in disease prevalence and phenotypes, but the extent to which differences are caused by genetic factors is unknown for most complex traits. Comparing phenotypic means across populations is confounded by environmental differences and using polygenic predictors can lead to biased inference1,2. Fa...
Si-Qi Wang, J. Berumen, A. Vergara-Lope et al.· Nature· 0 citations
Despite metabolomics transforming our understanding of risk factors and aetiology of metabolic diseases, profiling is rarely performed for people of non-European ancestries, on whom much of metabolic disease burden falls. Metabolome-wide association studies (MWAS) can be performed using genetic scores to predict metabo...
T. Oreskovic, D. Jin, E. Trichia et al.· medRxiv· 0 citations
Elevated BP as a major modifiable risk factor for kidney failure mortality, CKD, and albuminuria is highlighted in this large prospective study in Mexican adults.
Doreen Zhu, P. Kuri-Morales, Rachel Wade et al.· American Journal of Kidney D...· 0 citations
The primordial role of metabolic pathways and adipokines as therapeutic targets for HF management is highlighted, and six cardiomyopathy genes were novel for HF and associated with cardiac structure and function.
D. Rasooly, G. Peloso, C. Giambartolomei et al.· medRxiv· 0 citations
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