Derivation and Validation of Charlson, Elixhauser and RxRisk Cost-Based Comorbidity Indices: A Register-Based Study of 350,000 Individuals Over 11 Years.
BACKGROUND Comorbidity indices are widely applied to adjust for confounding in observational research. However, health economic analyses often adjust for comorbidity using mortality-based indices, despite health conditions being likely associated differently, both in terms of magnitude and direction, to resource use th...