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Tregs engineered with an orthogonal IL-2 tethered to its receptor persisted without exogenous IL-2 and exhibited superior therapeutic efficacy in a mouse model of type 1 diabetes.
A combination of in vivo and NAM-based nonclinical safety framework for CAR-Treg therapies is established and it is demonstrated that CAR engineering of SBT777101 does not introduce new safety liabilities relative to unmodified polyclonal Tregs.
Regulatory T (Treg) cells in mice can lose lineage identity and acquire proinflammatory functions, but whether human Treg cells are similarly susceptible to cytokine-driven destabilization remains unclear. Here we established an in vitro model of human Treg cell destabilization defined by silencing of the lineage-speci...
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