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J. Brägelmann

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Open access Aug 2026

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...

Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al. · 0 citations

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