Beyond Exons 19 and 21: mapping the clinical and molecular diversity of uncommon EGFR mutations in a Brazilian NSCLC cohort.
BACKGROUND Uncommon and complex EGFR variants respond variably to tyrosine kinase inhibitors, and data on their frequency in Brazil are scarce. METHODS We retrospectively analysed 141 patients with EGFR-mutated lung adenocarcinoma at a single Northeastern Brazilian centre. All profiling used treatment-naive diagnosti...