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J. C. Schmidt

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Open access Sep 2026

Dynamic chromatin tethering of MDC1 regulates genome stability

Abstract DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions because they disrupt the connectivity of the DNA strand. Homologous recombination (HR) is a high-fidelity DSB repair pathway that copies the sequence spanning the break from a homologous template, but how DNA ends are held together during HR rema...

Joshua R. Heyza, Mariia Mikhova, Cody Phillips et al. · 0 citations

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