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Author

J. Casement

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2 papers indexed here

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Sep 2026

Differential BET protein recruitment to IL6 and IL8 promoters and suppression of inflammatory and cell cycle genes by BET inhibitor in keratinocytes.

Bromodomain containing BET proteins are druggable proteins which bind acetylated chromatin and are implicated in dysregulated gene expression in chronic inflammatory disorders. We set out to test whether BET proteins regulate inflammatory responses in keratinocytes, which are key effector cells in cutaneous inflammatio...

Keith C. P. Wu, N. Harker, S. Cockell et al. · 0 citations
Open access Sep 2026

Treatment-driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B-cell therapy in Sjögren's disease.

OBJECTIVE To characterise whole-blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti-CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non-response. METHODS Whole-blood RNA sequencing was performed at baseline and w...

A. Ibrahim, Jun-Jie Peng, Eileen Tian et al. · 0 citations

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