Pseudomonas aeruginosa relies on the redox cofactor pyrroloquinoline quinone (PQQ) for efficient glucose and ethanol metabolism via periplasmic dehydrogenases (Gcd and ExaA). While PQQ biosynthesis is well-characterized, its uptake mechanisms remain unclear. Here, we identify PA2289 (PqqU), a TonB-dependent transporter...
C. Paschalidis, Manon Ferry, Anne-Eloïse Revillot-Schmidt et al.· FEMS Microbiology Letters· 0 citations
Abstract Small regulatory RNAs (sRNAs) are key drivers of bacterial adaptation to environmental fluctuations, including iron and manganese restriction imposed by the host. This study explored the repertoire of sRNAs produced by the human pathogen Staphylococcus aureus in response to metal limitation. Two sRNAs were ide...
Mathilde Charbonnier, Hugo Racine, Samuel Probst-Lotze et al.· Nucleic Acids Research· 0 citations
All living beings use ribosomes to synthesize proteins from α-amino acids. Inherited from our common ancestor, a few universally conserved ribosome biogenesis steps, introducing essential ribosomal RNA modifications, have survived to our days. However, it was unknown whether similar primordial core mechanisms could als...
Bruno Bonnettaz, Anna Smirnova, Marlène Vayssières et al.· bioRxiv· 0 citations
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