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Open access Sep 2026

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

Pancreatic cancer (PC) is largely refractory to immune checkpoint blockade (ICB), although homologous recombination-deficient (HRD) tumors may derive benefit. In the POLAR trial of maintenance pembrolizumab plus olaparib after platinum-based chemotherapy for metastatic PC, responses remained heterogeneous. To define de...

M. Hilmi, J. Schoenfeld, Wilson H. McKerrow et al. · 0 citations
Open access Jul 2026

Improving preoperative risk stratification in colorectal liver metastases: a multi-institutional evaluation of multimodal prediction models.

Reliable prognostic models of death or liver recurrence following resection of colorectal liver metastases are critical to stratify patients for treatment. The study aimed to develop models incorporating clinical and imaging data into multimodal preoperative prediction models of hepatic disease-free survival and overal...

Kaitlyn Kobayashi, R. Mojtahedi, E. C. Bunker et al. · 0 citations

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