Targeting estrogen to the brain via DHED does not seem to protect against metabolic dysfunction in obese OVX mice
Abstract Menopausal hormone therapy (MHT), prescribed for climacteric symptoms including hot flushes and weight gain, contains estrogens such as 17 beta-estradiol (17βE2). However, estrogen receptor activation by MHT may increase reproductive cancers in some people. As the protective metabolic effects of 17βE2 are part...