Open access
Aug 2026
Multi-omics approaches reveal direct NF-κB p65 target genes in pancreatic islets during cytokine exposure and in Type 1 diabetes
Findings clearly show that IL-1β signaling in pancreatic β-cells directs p65 to specific genomic regions congruent with increased gene expression relevant to T1D in β-cell lines as well as mouse and human islets exposed to cytokines.
Thomas M. Martin, Susan J. Burke, Heidi M. Batdorf et al.
· American Journal of Physiolo... · 0 citations